Glutamine deamidation: an indicator of antiquity, or preservational quality?
نویسندگان
چکیده
منابع مشابه
Transamination and associated deamidation of asparagine and glutamine.
With this system, no deamidation of glutamine occurred in the absence of a-keto acid, and, with all keto acids tested except two (pyruvate and a-ketobutyrate), transamination was absent or extremely slow when glutamate was substituted for glutamine. Experiments with W-labeled glutamine indicated that the ammonia evolved during this reaction was derived from t.he amide group of glutamine. Althou...
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Glutamate is known to inhibit the activity of isolated glutaminase I; however, its actual physiologic importance in regulating renal ammoniagenesis has not been established. To determine the regulatory role of glutamate on the metabolism of glutamine by rat kidney slices, we followed the effects on glutamine (2 mM) deamidation of increased removal of glutamate via augmented deamination. Three a...
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متن کاملDeamidation reactions of protonated asparagine and glutamine investigated by ion spectroscopy.
RATIONALE Deamidation of Asn and Gln residues is a primary route for spontaneous post-translational protein modification. Several structures have been proposed for the deamidation products of the protonated amino acids. Here we verify these structures by ion spectroscopy, as well as the structures of parallel and sequential fragmentation products. METHODS Infrared ion spectroscopy using the f...
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ژورنال
عنوان ژورنال: Rapid Communications in Mass Spectrometry
سال: 2015
ISSN: 0951-4198
DOI: 10.1002/rcm.7445